S-05 · Custom method development

Novel compound? Novel method.

For compounds outside our standing catalogue, we develop, optimise, and validate the analytical method — then hand you the full ICH Q2(R1) validation dossier ready for regulatory submission.

Duration
4–8 wk
Validation
ICH Q2(R1)
Sample req.
Consultation
Deliverable
Validation dossier
Method reference
MA-S05-DEV-01
Instrument-calibrated● ValidatedSigned releaseRaw data retained
Method sheetHK · Kwun Tong
§ 01 — Assay scope

What is measured.

Every attribute is quoted, run, and reported against the same reference method. Add-ons run from the same submission.

A-01SoW

Scoping & feasibility

Compound review, matrix assessment, and a written scope of work with milestones.

A-02HPLC · LC-MS

Method development

Column screening, gradient optimisation, and detector selection. Iterated to fit-for-purpose.

A-03ICH Q2(R1)

Validation

Specificity, linearity, accuracy, precision, LOD/LOQ, robustness, and range.

A-04SOP

Transfer & training

Method transfer package for your internal lab or a partner CRO, with signatory training.

§ 02 — Method sheet

MA-S05-DEV-01

Abbreviated method sheet. Full validated method (linearity, robustness, system suitability) available under NDA.

Phase 1
Feasibility & scope · 1 week · fixed fee
Phase 2
Development · 2–4 weeks · progress report weekly
Phase 3
Validation · 2–3 weeks · full ICH Q2 package
Phase 4 (opt.)
Method transfer & signatory training · 1–2 weeks
Governance
Change-control log · every parameter change signed and dated
Reference
ICH Q2(R1) · Q14 · FDA analytical procedures guidance
IP
Method IP owned by client · ALS retains no rights of use
§ 03 — Deliverable

A certificate you can hand to a regulator.

  • Validated SOP with system-suitability criteria
  • Full ICH Q2(R1) validation report (submission-ready)
  • Raw data package: chromatograms, spectra, integration logs
  • Method transfer package with acceptance criteria
  • IP-clean — validated method is yours to run anywhere

Submit a sample.

Tell us the compound and quantity. We reply with a scoped quote and shipping label within one business day.